The left-arm pacer claimed a quartet of wickets in the final innings following going wicketless in the first innings.
First Test, the Gaddafi Stadium (day four)
Pakistan 378 (Imam-ul-Haq 93, Agha 93; Senuran Muthusamy 6-117) & 167 (Babar 42; the spinner 5-57)
The visitors 269 (De Zorzi 104; Noman 6-112) & 183 (Dewald Brevis 54; Shaheen 4-33, Noman Ali 4-79)
Pakistan won by 93 runs
The national team brought an end to the reigning champions South Africa's winning streak by sealing a 93-run margin victory in an thrilling and closely contested first Test in Lahore.
South Africa, whose 10-Test unbeaten run in the longest format culminated in victory over the Aussies in the World Test Championship final in the month of June, were dismissed for 183 chasing 277.
Starting the day on 51-2, they saw the dismissal of first-innings centurion De Zorzi lbw to pace bowler Shaheen Afridi to the third ball of the day to shift the finely-poised chase in the home team's favor.
Left-arm spinner Noman Ali, who took 10-191 in the game, removed Stubbs for 2 and clean bowled Dewald Brevis, who offered some resistance with a run-a-ball 54.
Right-arm spinner Sajid Khan also capitalized on sharp turn to end opener Ryan Rickelton's stay - he lasted 145 balls for 45 runs - and Afridi returned in the post-lunch session to dismiss the lower order with a fine display of reverse-swing bowling.
He trapped Verreynne lbw for 19 and bowled Subrayen and Kagiso Rabada to seal the win.
It was each team's opening game of the 2025-27 World Test Championship cycle and propels Pakistan directly into the number two spot after leaders the Australian team.
Their victory was built around contributions of ninety-three by opener Imam and, crucially, number seven Salman Agha which boosted them to 378.
From there spinners Noman Ali and Sajid Khan took advantage of helpful home pitches, as they had in their Test series win over England the previous year, to maintain their advantage.
The second and last match begins on 20 October.